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MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors.

Lung Cancer. 2017;

RothschildSacha I，GautschiOliver，BatlinerJasmin，GuggerMathias，FeyMartin F，TschanMar

Products/Services Used	Details	Operation
Catalog Antibody	… used include: anti-Procaspase 12, anti-Caspase 9, anti-Caspase 6, and anti-GAPDH (Chemicon, MA); anti-cleaved Caspase 3 (Cell Signaling Technologies, MA), anti-BNip1 (BD Biosciences, CA), anti-Hif-1alpha (Novus Biologicals, CO), anti-p53 (Genscript, NJ), anti-H2B …	Get A Quote

摘要

Src tyrosine kinase inhibitors (TKIs) significantly inhibit cell migration and invasion in lung cancer cell lines with minor cytotoxic effects. In clinical trials， however， they show modest activity in combination with chemotherapeutic agents. Possible resistance mechanisms include the induction of cytoprotective autophagy upon Src inhibition. Autophagy is a cellular recycling process that allows cell survival in response to a variety of stress stimuli including responses to various treatments.